4^th World Liver Congress

Liver Regeneration

The liver is a visceral organ which has a unique power of regeneration, this property is called homeostasis, in spite of surgically removed the liver can grow back to a full size. Liver regeneration involves the regeneration of liver cells like hepatocytes which possess an unlimited capacity for proliferation, sinusoidal endothelial cells, and biliary epithelial cells. It is a highly controlled process regulated on highly redundant signals by complex pathways and these signaling pathways are known to stimulate by growth factors, hormones, cytokines, and nuclear receptors but the excess accumulation of fats may interfere with the regeneration mechanism of the hepatocytes.

·The clonogenic capacity of hepatocytes

·Proliferation and differentiation

·Hepatocyte growth factor

·Other factors