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Jian Guan

Jian Guan

Peking Union Medical College China

Hussien Elsiesy

Hussien Elsiesy

King Faisal Specialist Hospital & Research Center Saudi Arabia

Amr Amin

Amr Amin

UAE University UAE

Mark A Feitelson

Mark A Feitelson

Temple University USA

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Trent W Nichols

AMRI USA

Mamdooh Ghoneum

Mamdooh Ghoneum

Charles Drew University USA

Steven Teich

Steven Teich

Levine Children’s Hospital USA

Khalil N Bitar

Khalil N Bitar

Wake Forest School of Medicine Winston Salem USA

Liver Congress 2018

About Conference


About Liver Conference

Liver Congress 2018 takes a lot of privilege to invite all the scholars and researchers from all over the world to expatiate about their respective scientific research at “3rd World Liver Congress”. An opportunity to experience this grand colloquium along with the most alluring city Abu Dhabi, UAE on October 15-16, 2018 .and theme of the conference is “Exploring new pathways through discoveries in making Liver healthy”. Liver Congress 2018 is a unique platform for a focused plan of the current research in the field of hepatology which includes prompt Keynote presentations, Oral talks, Poster presentations, Delegate views, board talks, and Exhibitions. We invite Gastroenterologists, Hepatologists, cardiologists, neurologists, nephrologists, General Physicians, Microbiologists, Virologists, Pathologists, Oncologists, Surgeons and Toxicologists, Researchers, Students, Business delegates and Young researchers across the globe.

Why attend?

It is a worldwide platform for people around the world to discuss liver and liver-related diseases, this is best opportunity to accomplish the greatest gathering of participants from around the world to conduct presentations, distribute and update knowledge. This liver Congress 2018 will coordinate, disperse information and meet with recurring pattern and potential investigators and get name affirmation at this 2-day event. Broadly World-eminent speakers and researchers with the most recent frameworks, methodologies, and the most current updates in the field of the liver in connection various branch of medicine, are indications of this conference. This International Conference on the liver or rather all liver and Hepatology gatherings, liver events and liver congress will help in specialists, academicians and frameworks organization.

Target Audience

  • Deans and Professors of medicine and Hepatology departments
  • General Physicians
  • Doctors
  • Business Professionals
  • Medical Colleges
  • Scientists and Researchers organizers
  • Research Scholar
  • Consultants
  • Lab Technicians
  • Healthcare professionals
  • Founders and Employees of the related companies
  • Clinical investigators & Researcher
  • Hospitals and Health Services
  • Pharmaceutical companies
  • Nurse and nursing education institutions

 

Sessions/Tracks

Track 1: Cellular and Molecular Gastroenterology & Hepatology

Gastroenterology is the branch of medicine with deals the digestive system and its disorders. Gastroenterology deals with the diseases affecting the gastrointestinal tract, and its related organs starting from the mouth to the anus. Hepatology is also the branch of medicine with deals with the study of gallbladder, liver, pancreas and biliary tree and as well as their disorders. Cellular and Molecular Gastroenterology and hepatology allow us to investigate biology from the atomic level to the community level. Cellular and Molecular Gastroenterology and Hepatology elements the most recent discoveries with respect to the liver structure and function other organs from the atomic level to organ level.

Track 2: Liver Inflammation and Immunology

The human liver is perceived as a non-immunological organ which primarily engaged in metabolic, nutrient storage and detoxification activities but it has many unique immunological properties, including induction of immune tolerance, strong innate immunity, poor adaptive immune response versus over-reactive autoimmunity and hematopoiesis in the fetal liver. The healthy liver is a site for immunological activity with a diverse immune cell repertoire as well as non-hematopoietic cell populations. The innate immunity like hepatocytes provides protection against hepatic and systematic bacterial infections.   Kupffer cells, also known as stellate macrophages and Kupffer-Browicz cells are specialized macrophages located in the liver, lining the walls of the sinusoids that form part of the mononuclear phagocyte system.

Track 3: Liver Regeneration

The liver is a visceral organ which has a unique power of regeneration, this property is called homeostasis, in spite of surgically removed the liver can grow back to a full size. Liver regeneration involves the regeneration of liver cells like hepatocytes which possess an unlimited capacity for proliferation, sinusoidal endothelial cells, and biliary epithelial cells. It is a highly controlled process regulated on highly redundant signals by complex pathways and these signaling pathways are known to stimulate by growth factors, hormones, cytokines, and nuclear receptors but the excess accumulation of fats may interfere with the regeneration mechanism of the hepatocytes.

  • The clonogenic capacity of hepatocytes
  • Proliferation and differentiation
  • Hepatocyte growth factor
  • Other factors

Track 4: Gene Expression in Liver

There is a higher genetic diversity in tumor cells which holds at the gene expression level. Through knowing the gene expression level we can regulate the hepatocellular carcinoma during hepatitis viral infection. Disease progression in HBV and HCV induced can influence by both environmental factors and genetic risk factors. Nucleic acid-mediated gene therapy has been undergoing clinical trials which may result towards prevention of chronic liver diseases by regulating mechanism of different proteins expression using miRNA overexpression and miRNA functional silencing.

  • Genetics and epigenetics of liver cancer
  • Human liver proteome project

Track 5: Hepato-nephrology

Hepato-nephrology is the field that deals with how the liver disease is affecting the kidney function. Hepatorenal syndrome is the medical condition that occurs in patients suffering from fulminant liver failure, alcoholic hepatitis, and cirrhosis which results in rapid deterioration of kidney function with an infection, bleeding in the gastrointestinal tract or overuse of diuretics. Patients show other symptoms like jaundice, altered mental status, evidence of decreased nutrition, the presence of ascites and elevated pressures in the portal vein system, elevated pressures in the portal vein system.

Track 6: Hepato-Cardiac Disorders

Hepato-cardiac disorders are defined as the liver disease affecting the heart or the heart disease affecting the liver or the condition affecting heart and liver at the same time. During the Differential diagnosis of liver injury or disease, in a cardiologist, clinical practice, ask for collaboration between the hepatologists and cardiologists. In patients with the advanced liver disease may show and various abnormalities like some diastolic and systolic dysfunctions, reduced cardiac performance. Cardiac evaluation in liver disease patients is important, after a liver transplantation may improve cardiac function or have reversal effect. Systemic disease with effect liver and heart are congenital, inflammatory and metabolic and alcoholism.

  • Portal hypertension
  • The hepatopulmonary syndrome
  • Hepatic hydrothorax

Track 7: Liver Cancer

Liver cancer is the condition which occurs when normal cells in the liver become abnormal in appearance and destructive to the adjacent normal tissues, which can spread to other areas of liver or to the other organs outside of the liver. Cancer cells are characterized by the procurement of several capacities amid the stages of tumorigenesis, maintenance of proliferation signaling, induction of angiogenesis, activation of invasive resistance to cell death, inhibition of growth suppressors, and metastatic pathways, ability to evade immunological destruction and alteration of cellular metabolism. The clonogenic capacity of stem cells was evaluated by the stem cell colony formation assay.

  • Liver cell carcinoma
  • Hepatocellular carcinoma
  • Hepatoma
  • Cholangiocarcinoma
  • Hepatoblastoma
  • Angiosarcoma of liver
  • Kupffer cell sarcoma
  • Other sarcomas of liver

Track 8:  Neurology and Liver Disease

Neurological deficits related to liver illness may influence the CNS, the peripheral nervous framework, or both. The most serious neurological complication of acute liver failure and hepatic encephalopathy result in the advancement of the brain oedema. Cognitive dysfunction is detected in Hepatitis C along with serious fatigue and mood disorders. Alterations in the brain metabolites show CNS change in these patients when recognized by magnetic resonance spectroscopy. The most widely recognized aspect of this relation is that hepatocellular failure may be complicated by the behavioral syndrome of hepatic encephalopathy, in which neurotransmission in the brain altered, profound fatigue in patients with chronic cholestasis is, may also be associated with altered neurotransmission in the brain.

  • HCV/HIV Co-infection epidemiology
  • Wilson Disease

Track 9: Hepatic Pathology

Histological examinations of liver biopsy before treatment showed accumulation of fat within the hepatocytes, bile duct endothelium and epithelium and kupffer cells which contain the portal macrophages. The liver serves as the filtration ground of absorbed intestinal luminal contents which are particularly susceptible to microbial antigens.

Track 10: Pediatric and Geriatric Hepatology

Liver diseases are mostly seen as in a grown-up, however, a huge number of children from babies to teens experience from different types of liver diseases. The volume of the liver and the blood flow decreases with age, immune responses against pathogens or neoplastic cells are lower in the elderly reducing their tolerability to treatments for liver diseases. Liver regeneration capacity shows a decline in age, reduced proliferation of hepatocytes, but the level of hepatic enzymes and high-density lipoprotein cholesterol is well maintained. Pediatric hepatology focuses on the diagnosis and treatment of liver and liver-related disease in infants and children.

  • Gilbert’s disease
  • Hemochromatosis
  • Liver Failure
  • Liver Cirrhosis
  • Hepatorenal syndrome
  • Liver Fibrosis
  • Neonatal Jaundice

Track 11: Hepato-Biliary Diseases

Hepato-biliary disease includes a heterogeneous group of liver and biliary system caused by bacterial, viral and parasitic infections, toxic chemicals, alcohol consumption, metabolic disorders, cardiac failure, and neoplasia. Some of the hepato-biliary diseases appear to be a genetically determined metabolic trait; the physiological abnormality underlying the formation of gallstones is an accumulation of bile supersaturated with cholesterol causing cholesterol gallstones. Recent progress in the molecular biology and genetic control of lipoproteins and lipids metabolism may provide an opportunity for new studies on these diseases.

Track 12: Hepatitis

Hepatitis occurs due to the inflammation in tissues of the liver caused due to the viral infection which can harm the organ which may further lead to cirrhosis, fibrosis and liver cancer. Hepatitis is a devastating disease that progress slowly but results in damage to the liver. Hepatitis A is the most common cause’s acute hepatitis in children in Middle East. Establishment of HBV vaccination to cover all neonates and high-risk group, screening of donor blood can help in improving the case. Recent advancement in the treating hepatitis built on incremental improvements can transform it to new forthcoming treatments that can be potentially cured.

  • Autoimmune hepatitis
  • Alcoholic hepatitis
  • Viral Hepatitis

Track 13: Liver Disease and Pregnancy

Certain liver diseases are uniquely associated with pregnancy like Hyperemesis gravidarum is intractable, dehydrating vomiting in the first trimester of pregnancy occurs due to liver dysfunction. Intrahepatic cholestasis of pregnancy is pruritus and elevated bile acids in the second half of pregnancy, accompanied by high levels of aminotransferases and mild jaundice. The common condition in hepatic tenderness and liver dysfunction in pregnancy is severe preeclampsia it is further complicated by low platelet count, elevated liver tests, and haemolysis. Signs and symptoms of liver disease in pregnancy is not specific, fertility can be restored by liver transplantation by this pregnancy may have a good outcome.

  • Hyperemesis gravidarum
  • Intrahepatic cholestasis of pregnancy
  • HELLP syndrome

Track 14: Liver Transplantation and Surgery

Liver transplant is an operation that replaces a replaces a person’s diseased heart with a partial or a whole liver from a donor. A rare condition in newborn infants is Biliary atresia in which the common bile ducts, which carry bile out of liver and present between the liver and small intestine is absent or blocked. Bariatric surgery performed on people, who have obesity through a variety of procedures. Removing a tissue sample (biopsy) from the liver may help diagnose liver disease. Liver biopsy is done using a long needle inserted through the skin to extract a tissue sample and then analyzed in a laboratory.        

  • Immunosuppressive management
  • Graft rejection
  • Living donor transplantation
  • Bariatric surgery
  • Liver Biopsy

Track 15: Liver Imaging Modalities

Liver imaging is basically for precise diagnosing biliary tract issue and is imperative for identifying liver injuries or damage and patients with a suspected malignancy is important because the liver is the common site of metastatic spread and those who are at the risk of developing hepatocellular carcinoma.

  • Ultrasonography
  • Computerized Tomography
  • Magnetic Resonance Imaging
  • Angiography
  • Positron Emission Tomography
  • Steatohepatitis and Fatty Liver

 

Market Analysis Report

Scope and Importance:

Liver Congress 2018 have invited worldwide experts on Hepatology, cardiology, neurology, Gastroenterology, and Endoscopy, they will give lectures and will demonstrate the latest developments in Hepatology in complementarity with cardiology, neurology, obesity, Gastroenterology & Pregnancy, Hepatitis & Liver Diseases, microbiology during the presentations. New scopes will be shown as new accessories.

Hepatology is a sub-specialty of gastroenterology that incorporates the study of liver, biliary tree, gallbladder and pancreas as well as management of disease and disorders associated with them. Some of the cases associated with liver include jaundice, liver cancer, liver transplantation, drug overdose, biliary infection bleeding, pancreatitis, GIT bleeding, etc. Although there is a reduction in deaths due to gallstone disease and gallbladder cancer, liver-related mortality has remained relatively stable over the last 30 years. Hepatology represents a growing problem for the international healthcare systems and first of all, for the patients.

Why Abu Dhabi?

Nearly 30 percent of the UAE’s adult population could be suffering from non-alcoholic fatty liver disease, a condition that is closely linked to diabetes and metabolic syndrome, medical professionals have warned. And without proper care, the disease could significantly increase the risk of developing cardiovascular complications and liver damage. About 51 Emirati patients have so far undergone living donor liver transplants at our facility, and they make up the largest ethnic group among our patients. About 43% of all Emirati patients who had liver cancer had undergone liver transplantation and 32% have been suffering from liver damage from hepatitis B and C. In fact, most ultrasounds do not pick up on fatty livers unless 30 percent of the organ’s mass is made up of fat. And it is likely that prevalence rates in the UAE are similar to the United States’ prevalence of 20 to 30 percent of the adult population.

 

 

The above graph represents the number of death of people with liver cancer and various liver diseases in comparison to the world and among the continents.

Most of the liver death results due to the alcohol consumption, viral hepatitis and various types of liver cancers. The above graph represents people mortality rate in reference to alcohol consumption, liver cancer, hepatitis and other liver diseases.

 

In the above graph, represents the number of death per individual has been reduced in few decades, the number death per 100,000 people in the year 1986 and 2017 were plotted, with the development in the field of research and advancement in liver hepatology have reduced the annual deaths.

Great progress has been made in the field of liver transplantation over the decades, however, the progress has brought up quite a few challenges like shortage of organs and organ donors and large proportion waiting list of patients. There has been a significant effort in the improving the number of the donor pool. With the improvement in the understanding the pathophysiology of liver allograft, conditions, like the cardiac arrest various factors can be improved which will in turn help in the development of mechanical perfusion strategies. Long-term results of liver transplant recipients have not improved significantly, as recipients continue to succumb to complications of long-term immunosuppression, such as contamination, malignancy, and renal failure. Furthermore, recent evidence suggests that unremitting immune-mediated injury to the liver may also affect graft function.

Evolution of HCV Therapy:

In the United States, 20 percent to 30 percent of individuals living with HIV are co-infected with HCV. Hepatitis C is common among individuals living with HIV. This implies that approximately 225,000 to 330,000 individuals in the United States are living with both viruses. The larger part of individuals living with hepatitis C does not know they have it. The most common course of transmission in the UK is utilizing non-sterile needles and other equipment for infusing drugs. 90 percent of individuals who got HIV from infusing drugs are moreover infected with HCV. This is since both infections can be spread effectively through blood and blood products.

 

 

Major society and Association related to Liver

Middle East

Saudi Gastroenterology Association

Emirates Gastroenterology & Hepatology Society

Yemen Gastroenterological Association

Turkish Society of Gastroenterology

The Israeli Society of Gastroenterology and Liver Disease

Iraqi Society of Gastroenterology and Hepatology

Iranian Association of Gastroenterology and Hepatology

Globe

American Liver Foundation

The Japan Society of Hepatology

The Asian Pacific Association for the Study of the Liver [APASL]

Hepatology Society of the Philippines

European Association for the Study of the Liver (EASL)

International Liver Cancer Association

American Association for the Study of Liver Diseases (AASLD)

The International Association for the Study of the Liver

The Egyptian Society of Hepatology, Gastroenterology and Infectious Diseases in Alexandria (ESHGID)

The 43rd European Society for Paediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN)

World Hepatitis Alliance

The Coalition to Eradicate Viral Hepatitis in the Asia Pacific

International Coalition of Hepatology Education Providers

Eurasian Gastroenterological Association

Australasian Hepatology Association

Chinese Society of Gastroenterology

Egyptian Association for the Study of Gastrointestinal and Liver Disease

Gastroenterological Society of Australia

Gastroenterological Society of Singapore

The Gastroenterological Association of Thailand

Hepatology Society of the Philippines (HSP)

Indian National Association for Study of the Liver (INASL)

Indonesian Association for the Study of the Liver

South Asian Association for the Study of the Liver

 

New Updates- Liver Congress 2018

Can Food-derived antioxidants halt or prevent fatty liver disease?

As there is an increase in obesity in the world, non-alcoholic liver disease (NAFLD) has become a major health issue, in turn, increasing liver transplants and cancer. The non-alcoholic fatty liver disease is characterized by excessive lipid accumulation in hepatocytes which further leads to various liver disease. There are many anti-inflammatory, anti-oxidants, insulin sensitizer dietary supplements which show beneficial effects on NAFLD.

An anti-oxidant found in papaya, celery, parsley and in kiwi fruit called pyrroloquinoline quinone (PQQ) which can halt or prevent the progression of fatty liver. Most childhood obesity and fatty liver disease are influenced by the infant’s microbiome and maternal diet. According to the results, the significance of neonatal period is an important window to protect obese offspring from the ill effects of diet-induced lipotoxicity and potentially halt the increasing NAFLD associated with childhood obesity.

Overconsumption of high-fructose corn syrup in soda and fat forming, pro-inflammatory effects which appear in the transient ATP stage can lead to the formation of uric acid. The normal level of uric acid acts as anti-oxidants but the high level can harm the cells and also associated with the increased risk of developing high blood pressure, diabetes, kidney disease and obesity.

Prevention:

Fructose: similar to alcohol can damage our body and liver

Eating right and exercising can prevent this condition and reverse at its early stage.

 

Development of a xenograft model zebrafish to study the liver cancer cell lines

Most occurring disease in the liver is Hepatocellular carcinoma which affects nearly a million every year, affects in people having Hepatitis B and C infection which is also associated with the cirrhosis mainly caused due to exposure of aflatoxin B, chronic alcohol use. Liver cancer patients show the difference in prognosis, so it's important to discover the target genes and ACHE Acetylcholinesterase is the target gene, any change in the amount of ACHE is associated with cancer prognosis and can be degraded by the enzymatic action of acetylcholine. Recombinant ACHE treatment decreases cell proliferation in liver cancer cell lines expressing themselves in mice xenograft model decreases tumor size.

Xenograft models for liver cancer have been developed in different organisms; use of multiple tumor cells has been proposed to observe different tumor phenotypes. Having a hundred transparent offspring enabling ease of imaging and lack of early developmental adaptive immune system, made them emerge as a model for tumor xenotransplantation studies.

 

Alcohol-induced bone marrow damage or Bone marrow Suppression from Alcohol abuse

Bone marrow is responsible for producing white blood cells, red blood cells, and platelets. A direct result of alcohol abuse is to liver, brain, and heart but apart from that, it results in low platelets, anemia, and leukopenia. WBC provides resistance to infections and RBC is vital for transporting oxygen and energy. Excessive drinking cause’s destruction of WBC and RBC and platelets, as it interferes with the production of the cells making the person weak, tired and vulnerable to the infection.

Bone marrow suppression results in paroxysmal nocturnal hemoglobinuria known as blood in the urine and Myelodysplastic Syndrome which is characterized by mutated cells, Alcoholism is the leading cause of thrombocytopenia. Alcohol adversely affects osteoblast activity, suppressing new bone formation needed in both normal bone remodeling and fracture healing, Studies show that bone-marrow biopsy samples from alcoholics are abnormal approximately two-thirds reveal sideroblastic and or megaloblastic changes and fewer shows iron deficiency and  the marked hemolysis of spur cell anemia found in patients with jaundice and severe alcoholic cirrhosis. Generalized reduction in blood cell numbers is not progressive or fatal and is reversible with abstinence, complex aberrations of hematopoiesis can develop over time which may cause death.

 

Gut Health Issues — Microbiome and Nonalcoholic Fatty Liver Disease

The microbiome in our body is made of 100 trillion bacteria which lines the gut. These type of bacteria that flourish or perish have a substantial impact on our health and on liver health.

Study based on obese people found that microbiome had a reduced type of bacteria called Bacteroidetes and an abundance of another bacteria called Firmicutes. This ratio Firmicutes to Bacteroidetes lead to an increase in lipopolysaccharide absorption.

Lipopolysaccharides are component of the cellular membrane of gram-negative bacteria like Bacteroidetes. Endotoxins like Lipopolysaccharides that trigger an inflammatory response in the body which contributes directly to the resistance of insulin in the liver and obesity.

The microbiome is unique in every human being it differs due to the diet. Based on the type of diet reduces the diversity of the microbiome, favoring an increase in the Firmicutes-to-Bacteroidetes ratio in the gut. As a result, causing obesity-microbiota profile that favors the development of obesity and fatty liver disease. As the lipopolysaccharide absorption increases, due to the poor diet and increase of microbiome destabilizes the liver function and non-alcoholic liver disease progress to non-alcoholic steatohepatitis.

Dermatological Manifestation of Gastrointestinal Disease

The liver is the metabolic production line of the body which produces energy to maintain functions performed in the body cells. The hair follicles require the energy to develop strong shiny hair and skin cells require vitality to eliminate toxins and regenerate and repair themselves. In the event that the liver does not work appropriately, the toxins would not be broken down and would be eliminated through other means like skin cells.

The excessive toxins would be deposited in the deep layers of skin causing inflammation and can give the ride to different disease like

•    Eczema

•    Dermatitis

•    Psoriasis

•    Acne and Acne rosacea (small pimples on face)

•    Red itchy rashes on the body

•    Wrinkling of skin and premature aging

•    Brown liver spots

•    Hives

There are different kinds of skin related problems, using conventional methods can suppress it, but comes with side effects, look for a deeper cause which is usually the liver and treat it with nutritional medicines.

A major variety of skin problems can be treated through various natural approaches:

•    The liver needs high requirement of antioxidants which is found in vegetables mostly green leafy and these antioxidants help in protecting liver cells from damage by detoxifying the bloodstreams, removing free radicals from skin cells which causes premature aging.

•    Omega 3 supplements present in fish oil helps in preventing chronic skin problems.

•  Selenium: a mineral that exerts anti-inflammatory effects in the body and is used for the production of glutathione which is an antioxidant.

Other liver-related problems:

Jaundice:  The symptoms of skin and the whites of the eyes look yellowish is due the to break down a chemical called bilirubin which builds up in the blood, and makes the skin turn yellow. It is the sign of infection with hepatitis C.

Itching:  The toxins that build up in the blood and because jaundice can also cause itching in hands and legs sometimes in the organs also.

Liver Toxicity and Drug Allergy

The liver main function is to purify blood by filtering out the toxins so that the body can absorb healthy nutrients that remain. Some drugs are directly injurious to the liver, other are transformed to chemicals by the liver.

Three types of toxicity

·         Dose-dependent toxicity-

·         Idiosyncratic toxicity

·         Drug allergy

Drugs that cause dose-dependent toxicity can cause liver malady in most individuals in case sufficient of the medication is taken.

Drugs that cause idiosyncratic toxicity cause disease in few patients who have inherited specific genes that control the chemical transformation of that specific drug by the accumulation of the drug or products of their metabolites that are harmful to the liver. The Inherited idiosyncratic toxicities are rare and depend on the drug. The idiosyncratic liver disease is the most common form of the drug-induced liver disease even though the risk of developing the drug-induced idiosyncratic liver disease is low.

Drug allergy is the most uncommon form of liver disease. There is inflammation of the liver that occurs when the body's immune system is attacked by the drugs with antibodies and immune cells.

Many drugs cause mild elevations in blood levels of liver enzymes without showing any symptoms or signs of hepatitis. AST, ALT, and alkaline phosphatase are enzymes that usually reside within the Hepatocytes and bile ducts and can cause the enzymes to leak from the liver cells into the blood, in a way elevating the blood levels of the enzymes.

The neurological manifestation of Acute Liver Failure

When the liver is damaged, the toxins or the poisons can build up in the bloodstream and influence the brain function and nervous system. Acute liver failure leads to the critical condition is known as brain swelling and as a rule, causes death in patients who suffer this complication. Preventing brain swelling and optimizing brain perfusion when brain swelling occurs it may be a critical component in making the option of good survivorship in patients with acute liver failure. Conventional approaches are made to limit the brain swelling and lowering intracranial pressure (ICP) which is not reliable in patients with ALF. While observing ICP is a critical step toward appropriately treating these patients, the ALF causes a coagulopathy that often creates hesitance for inserting an intrusive device into the cranium. An efficiently considered is done to approach, present and distributed comes about of demonstrating the safe insertion of ICP monitors in ALF patients without causing any noteworthy hemorrhagic complications. It is an important step toward changing the clinical approach to optimize brain perfusion and neurological outcome in ALF patients.

A strong interest is developed in the role of continuous hemodialysis techniques to facilitate ammonia clearance, and we have a project dedicated to correlate dialysis flow rates to the quality of ammonia clearance. The mechanism of brain swelling from ALF relates to hyperammonemia. The liver produces urea from ammonia as a by-product of protein metabolism. When there is an acute liver failure, the ammonia accumulates and is an important contributing factor to the development of brain swelling. The elevated level of ammonia in the astrocytes also known as brain cells is enhanced due to the conversion of glutamic acid to glutamine and this leads to cellular swelling further aggregate to brain swelling. High ammonia concentrations may have some toxic effects on neurons in addition to its role in astrocytic swelling

Cancer cells adapt to gorge on sugar within the liver

The Metastatic cancer cells can reprogram their metabolism to flourish in new organs. The finding shows that the colorectal cancer cells originating have changed their dietary habits to capitalize on the high levels of fructose often found in the liver. Cancer becomes much more deadly when it spreads to different parts of the body. In the study, it is found that certain metabolic genes became more active in liver metastases than they were in the original primary tumor or lung metastases. One group of metabolic genes was unique which are involved in the metabolism of fructose which in turn made the researchers think as because many Western diets are rich in fructose, which is mostly found all types of processed foods and in corn syrup.

When cancer cells are is proliferated into the liver, they use this ample new energy supply to create building blocks for growing more cancer cells. So they feed on fructose, which further makes the cancer cells to produce more of an enzyme which breaks down fructose, called ALDOB, which mostly done in the liver. The proliferation of cancer cells is quickened and become unstoppable, once they figure out how to adapt themselves to thrive on fructose. Besides providing an insight into how cancers thrive after metastasizing, this discovery can lead to new therapies specifically targeting metastatic cells. The fructose metabolism cannot be blocked but can be halt by avoiding fructose-containing non-processed foods, and by eating natural and providing drugs that block fructose metabolism. New drugs targeting fructose metabolism have recently been developed by pharmaceutical companies to treat the metabolic diseases.

Obesity May Impact Liver Health of Young Children

Obesity is the fastest emerging concern in the nation circuit and global health. According to the latest study it is found that there may be a negative impact on the liver health in children, may also accumulate fats in the liver by causing serious liver disease. Too much of fat accumulation in the liver may cause non-alcoholic liver disease which may progress to cirrhosis and later liver cancer.

NAFL is normally symptomless. Elevated ALT, the liver enzyme in the measured blood levels occurs in the person having the Non-alcoholic fatty liver disease. Children with bigger waist circumference also known as the measure of abdominal obesity are more likely have elevated ALT.

Measures:

One of the perfect ways for kids and adults to combat fatty liver disease is to lose weight the healthy way. Staying away from fried and processed foods, maintaining a strategic distance from sugary beverages and products, is additionally a must to manage weight better. Swap refined carb sources for whole grains. A whole grain could be a grain of any cereal that contains the endosperm, germ, and bran, in contrast to refined grains, which hold only the endosperm. A whole grain holds all the supplements that are processed within the refining. Stock up on whole grains like bajra, ragi, maize and jowar and utilize them frequently. Stack up on regular vegetables. They give both soluble and insoluble filaments in addition to vitamins, minerals, and antioxidants, which are exceptionally essential for a perfect state of health.

Gastric Drugs may heighten the risk of liver diseases

Proton Pump inhibitors are drugs that can reduce the gastric acid, but can promote the growth of a type of bacteria which is associated with chronic liver disease. These PPl are used to treat gastro-esophageal reflux disease which produce an uncomfortable burning sensation when travels up the oesophagus.

Our stomach produce gastric acid to inhibit the ingested microbes and taking medication to suppress gastric acid can change the micro-biome of the liver. Absence of gastric acid can promote the growth of Enterococcus bacteria which primarily lives in the intestine then translocate to the liver, where the cause inflammation and chronic liver diseases.

The effect of gastric acid suppression promotes a series of liver diseases

Alcoholic liver disease

Non-alcoholic fatty liver disease (NAFLD)

Non-alcoholic steatohepatitis (NASH) 

Past Conference Report

Hepatology 2017

With the support of organizing committee Hepatology 2017 4th International Conference on Hepatology at Hotel J W Marriott in Dubai, UAE during April 27-28, 2017.The conference was designed around the theme of “To create global awareness and to share novel approaches on treating Liver and Pancreatic Diseases” and was a great success where eminent keynote speakers from various reputed companies made their resplendent presence and addressed the gathering. Moreover, the networking sessions laid the foundation for some time worthy collaborations between many start-up and big industries. The post-conference networking lunch session witnessed a number of B2B meetings that are turning up to be mutually beneficial to both the organizations who had gone in for the business meetings.

Hepatology 2017 witnessed an amalgamation of peerless speakers who enlightened the crowd with their knowledge and confabulated on various new-fangled topics related to the field of Gastroenterology and Hepatology. This congress not only brought forward the latest developments in the field but also provided solutions to the numerous challenges encountered in developing Hepatology field.

Our organization would like to convey a warm gratitude to all the Honourable guests, Keynote Speakers, Delegates, Media Partners and Exhibitors for their participation in Hepatology 2017.

Keynote Speeches:

Vomiting of Surgical Significance

- Amin El-Gohary, Burjeel Hospital, UAE

Total mesopancreas excision for pancreatic head cancer: analysis of 120 cases

- Ying Bin Liu, Xinhua Hospital, China

Management of NAFLD in patients with DMT2

- Hendrick Reynaert, Vrije University, Belgium

Renal involvement in patients with hepatitis B

- Yuming Wang, Southwest Hospital, Third Military Medical University, China

Surgery of the Liver and intraoperative interventional Therapies What is possible today?

- Hani Oweira, Hirslanden Hospital, Switzerland

Microscopic hepatico biliary anastomosis in staged adult living liver transplant is a safe and
accessible choice

- Ali Ghannam, CGMH Kaohsiung, Taiwan

Speakers:

Maridi Aerts, University Hospital in Brussels, Belgium

Ahmed S. Ibraheem, Sohag University, Egypt

Abdel Rahman Abdulla Al Manasra, Jordan University of Science and Technology, Jordan

Abdulaziz Shaher, Assir Central Hospital, Saudi Arabia

Mohammad Firoz Alam, Jazan University, Kingdom of Saudi Arabia

Reju George Thomas, Chonnam National University Hwasun Hospital, South Korea

Hossien Kargar, Jahrom University of Medical Sciences, Iran

Rehan Saif, Aster DM Healthcare Group, India

Best Poster Award: 

Alexander Hann, Katharinen hospital, Stuttgart, Germany

Naglaa Raafat, Dubai Medical College for Girls, UAE

We are also obliged to various delegate experts, company representatives and other eminent personalities who supported the conference by facilitating active discussion forums. We sincerely thank the Organizing Committee Members for their gracious presence, support and assistance towards the success of Hepatology 2017. With the unique feedbacks from the conference, 3rd  International liver Conference to be held on October 15-16,2018 at Abu Dhabi and also invite you to participate at our Liver Congress 2018.

Let us meet again @ Liver Congress 2018

Top medical university in Europe

Wrocław Medical University

Brighton and Sussex Medical School

King's College London GKT School of Medical Education

Medical University of Silesia

School of Medicine, University of Zagreb

School of Clinical Medicine, University of Cambridge

Sheffield Medical School

Peninsula College of Medicine and Dentistry

Swansea University Medical School

Imperial College School of Medicine

Hull York Medical School

University of Birmingham Medical School

Leicester Medical School

Leeds School of Medicine

Southampton Medical School

Southampton Medical School

Bogomolets National Medical University

University of St Andrews School of Medicine

Top Medical University in USA

Harvard Medical School

Perelman School of Medicine

David Geffen School of Medicine at UCLA

University of California, San Francisco

Northwestern University Feinberg School of Medicine

Baylor College of Medicine

Pritzker School of Medicine

Columbia University College of Physicians and Surgeons

Boston University School of Medicine

Alpert Medical School

Top University In Asia

National University of Singapore (NUS)

Kyoto University

University of Hong Kong (HKU)

Peking University

Seoul National University (SNU)

National Taiwan University (NTU)

Osaka University

Tsinghua University

The Chinese University of Hong Kong (CUHK)

Fudan University

The Hong Kong University of Science and Technology (HKUST)

Taipei Medical University

Mahidol University

KAIST - Korea Advanced Institute of Science and Technology

Yonsei University

Shanghai Jiao Tong University

Nanyang Technological University (NTU)

Chulalongkorn University

Tohoku University

Tokyo Medical and Dental University

Kyushu University

Nagoya University

Hokkaido University

Sungkyunkwan University

University of Science and Technology of China

Pohang University of Science and Technology (POSTECH)

Korea University

Top Medical University in Middle East

American University of Sharjah

University of Jordan

Jordan University of Science and Technology

King Abdulaziz University

Khalifa University

Qatar University

American University of Beirut

Alfaisal University

King Saud University

Beni-Suef University

American University in Cairo

Suez Canal University

Imam Abdulrahman Bin Faisal University

University of Tunis El Manar

Sidi Mohamed Ben Abdellah University

University of Monastir

Sultan Qaboos University

University of Marrakech Cadi Ayyad

Mohammed V University of Rabat

Royal College of Surgeons in Ireland – Bahrain

Mohammed bin Rashid University of Medicine and Health Sciences

Gulf Medical University, Ajman

Dubai Medical College for Girls

Gulf Medical University Ajman

United Arab Emirates University

Ras al-Khaimah Medical and Health Sciences University

University of Sharjah

 

To Collaborate Scientific Professionals around the World

Conference Date October 15-16, 2018

Speaker Opportunity

Supported By

Journal of Liver Journal of Gastrointestinal & Digestive System Journal of Hepatology and Gastrointestinal disorders Journal of Gastrointestinal Cancer and Stromal Tumors

All accepted abstracts will be published in respective Conference Series LLC LTD International Journals.

Abstracts will be provided with Digital Object Identifier by


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Keytopics

  • Acute Liver Failure
  • Adenomas
  • Alagille Syndrome
  • Alagille Syndrome
  • Alcoholic Liver Disease
  • Ammonia Intoxication
  • Amyloid Liver
  • Angiogram
  • Angiosarcoma Of Liver
  • Anicteric
  • Artificial Liver
  • Asymptomatic
  • Autoimmune Hepatitis
  • Azobilirubin
  • Babesiosis
  • Bile Acids
  • Bile Canaliculi
  • Bile Duct Cancer
  • Bile Reflex
  • Biliary Atresia
  • Biliary Cirrhosis
  • Biliary Stasis
  • Biliary Stricture
  • Biliary Tract Diseases
  • Bilirubin
  • Bilirubin Diglucuronide
  • Biliverdin
  • Binding Protein
  • Bipotential Stem Cells
  • Breath Test
  • Budd-Chiari Syndrome
  • Cantlie's Line
  • Carcinogenesis
  • Caudate Lobe
  • Ceruloplasmin
  • Chemo-embolization
  • Chemotherapy
  • Chimerism
  • Cholangiocarcinoma
  • Cholangiocytes
  • Choledocholithiasis
  • Cholestasis
  • Cholestyramine
  • Cirrhoris
  • Clonorchiasis
  • Coagulation Test
  • Colorectal Diseases
  • Computed Tomography Scan
  • Coronary Ligament
  • Couinaud Classification System
  • Crigler-Najjar Syndrome
  • Cystic Duct
  • Cytomegalovirus Hepatitis
  • Digestive System
  • Distention
  • Dubin-Johnson Syndrome
  • Eclampsia
  • End Stage Liver Disease
  • Endothelial Cell
  • Enterohepatic Circulation.
  • Esophageal Varices
  • Esophageal Varices
  • Exocrine Pancreatic Function
  • Falciform Ligament
  • Fascioliasis
  • Fatty Liver
  • Fatty Liver Disease
  • Fecal Elastase
  • Fulminant Hepatic Failure
  • Gallbladder
  • Gallbladder And Biliary Disease
  • Gallstone Disease
  • Gallstones
  • Gastric Impression
  • Gauchers Disease
  • Gilbert's Syndrome
  • Gluconeogenesis
  • Glucuronidation
  • Glycogenesis
  • HELLP Syndrome
  • Hemochromatosis
  • Hemorrhoids
  • Hemosiderosis
  • Hepatic Allograft Rejection
  • Hepatic Dendritic Cell
  • Hepatic Encephalopathy
  • Hepatic Fibrosis
  • Hepatic Flexure
  • Hepatic Hemangioma
  • Hepatic Porphyria
  • Hepatic Sinusoids
  • Hepatic Steatosis
  • Hepatic Stellate Cell
  • Hepatitis
  • Hepatitis B Vaccine
  • Hepatitis Delta Virus
  • Hepatitis Surface Antigen
  • Hepatitis Virus
  • Hepato-Biliary Diseases
  • Hepatoblastoma
  • Hepatoblasts
  • Hepatocellular Carcinoma
  • Hepatocyte Growth Factor
  • Hepatomegaly
  • Hepatotoxicity
  • Homeostasis
  • Hyperbilirubinaemia
  • Hyperemesis Gravidarum
  • Hyperlipidemia
  • Hyperlipidemia
  • Icteric
  • Immune System
  • Immunoregulatory Proteins
  • Immunosuppression
  • Inflammatory Bowel Diseases
  • Intrahepatic Cholestasis Of Pregnancy
  • Intrahepatic Ducts
  • Irritable Bowel Syndrome
  • Jaundice
  • Kupffer Cell
  • Kupffer Cell Sarcoma
  • Lactate Dehydrogenase Test
  • Laparoscopy
  • Lipoproteins
  • Liver Biopsy
  • Liver Cancer
  • Liver Cirrhosis
  • Liver Cysts
  • Liver Disease
  • Liver Enzyme
  • Liver Failure
  • Liver Fibrosis
  • Liver Function
  • Liver Function Test
  • Liver Hematopoietic Progenitor Cells
  • Liver Homeostasis
  • Liver Imaging Modalities
  • Liver Immunity
  • Liver Injury
  • Liver Myeloid Immune Cell
  • Liver Regeneration
  • Liver Transplant
  • Liver Transplantation
  • Liver Tumor
  • Lymph Nodes
  • Magnetic Resonance Imaging (MRI)
  • Major Histocompatibility Complex
  • Malabsorption
  • Mesenteric Veins
  • Metabolic Liver Disease
  • Mycopheolate Mofetil
  • Neonatal Hyperbilirubinaemia
  • Nodular Hepatocellular Lesions
  • Nonalcoholic Fatty Liver Disease
  • Nonalcoholic Steatohepatitis
  • Nonalcoholic Steatohepatitis
  • Orthotopic Liver Transplantation
  • Paget's Disease
  • Pancreatitis
  • Partial Hepatectomy
  • Perisinusoidal Space
  • Phenobarbital
  • Platelet Count
  • Polycystic Liver Disease
  • Porta Hepatis
  • Portal Hypertension
  • Preeclampsia
  • Primary Biliary Cholangitis
  • Primary Biliary Cirrhosis
  • Primary Sclerosing Cholangitis
  • Prognosis
  • Prophylactic Antibiotics
  • Protein Kinase C
  • Pruritus
  • Radio Frequency (RF) Ablation
  • Radio-embolization
  • Rat Liver
  • Reyes Syndrome
  • Ribavirin
  • Rotor Syndrome
  • Sclerosing Mesesnteritis
  • Secondary Bile Acids
  • Serum Glucose Test
  • Spleen
  • Stable Isotope
  • Steatorrhea
  • Steatorrhea
  • Stercobilin
  • Steroids
  • Tacrolimus
  • Tissue Analysis
  • Tolerogenic Liver
  • Transferrin
  • Transhepatic Pancreato-cholangiography
  • Transjugular Intrahepatic Portosystemic Shunt
  • Transplant Hepatology
  • Transthyretin-related Hereditary Amyloidosis
  • Tumor Necrosis Factor
  • Ultrasound
  • Urobilinogen
  • Ursodeoxycholic Acid
  • Viral And Non-viral Hepatitis
  • Virological Response
  • Virus Infection
  • Wilson's Disease